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Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke

[ Vol. 15 , Issue. 2 ]

Author(s):

Chen-Shu Chang, Shih-Li Su, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Song-Shei Lin* and Chin-San Liu*   Pages 111 - 119 ( 9 )

Abstract:


Background: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke.

Method: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke. Subjects in both groups also underwent ultrasound B-mode imaging to measure the mean and maximum intima-media thickness of the carotid artery. Inflammatory biomarkers including high-sensitivity C-reactive protein and fibrinogen were also assessed.

Results: We found that the plasma concentration of Cyclophilin A was significantly higher in patients with acute ischemic stroke (p = 0.042). Increased Cyclophilin A was also correlated with carotid intima-media thickness in the patient group (p < 0.001). Among the risk factors for cerebral stroke examined in this study, only hypertension was significantly associated with plasma Cyclophilin A level.

Conclusion: Increased plasma Cyclophilin A levels might be involved in the pathophysiology of acute ischemic stroke and Cyclophilin A might serve as a biomarker in risk assessment of acute stroke patients.

Keywords:

Cyclophilin A, ischemic stroke, inflammation, atherosclerosis, reactive oxygen species, carotid intima-media thickness.

Affiliation:

Department of Medical Imaging and Radiological Sciences, Central-Taiwan University of Science of Technology, Taichung 406, Institute of Medicine, Chung Shan Medical University, Taichung, Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua 500, Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua 500, Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua 500, Department of Medical Imaging and Radiological Sciences, Central-Taiwan University of Science of Technology, Taichung 406, Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua 500



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