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MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy

[ Vol. 15 , Issue. 2 ]

Author(s):

Yi Yang, Ning Zhang, Shan Wang and Ya Wen*   Pages 103 - 110 ( 8 )

Abstract:


Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Subsequently, miR-155- induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway.

Keywords:

miR-155, autophagy, inflammatory response, ischemic cerebral tissues, ischemic stroke, hypoxic damages.

Affiliation:

Department of Neurology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory for Neurology, Hebei, 050000, Department of Neurology, The Second Hospital of Hebei Medical University, Hebei, 050000, Department of Neurology, The Second Hospital of Hebei Medical University, Hebei, 050000, Department of Neurology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory for Neurology, Hebei, 050000



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