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Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model

[ Vol. 15 , Issue. 3 ]

Author(s):

Qianchao He, Lingfei Jiang, Shanshan Man, Lin Wu, Yueqiang Hu and Wei Chen*   Pages 186 - 192 ( 7 )

Abstract:


Background: Epilepsy is a chronic neurological disorder affecting an estimated 50 million people worldwide. Emerging evidences have accumulated over the past decades supporting the role of inflammation in the pathogenesis of epilepsy. Curcumin is a nature-derived active molecule demonstrating anti-inflammation efficacy. However, its effects on epilepsy and corresponding mechanisms remain elusive.

Objective: To investigate the effects of curcumin on epilepsy and its underlying mechanism.

Method: Forty Sprague Dawley rats were divided into four groups: (1) control group; (2) Kainic Acid (KA)-induced epilepsy group; (3) curcumin group; and (4) curcumin pretreatment before KA stimulation group. Morris water maze was utilized to assess the effect of curcumin on KA-induced epilepsy. The hippocampi were obtained from rats and subjected to western blot. Immunohistochemistry was conducted to investigate the underlying mechanisms.

Results: Rats received curcumin demonstrated improvement of recognition deficiency and epilepsy syndromes induced by KA. Western blot showed that KA stimulation increased the expression of IL-1β and NLRP3, which were reduced by curcumin treatment. Further investigations revealed that curcumin inhibited the activation of NLPR3/inflammasome in epilepsy and reduced neuronal loss in hippocampus.

Conclusion: Curcumin inhibits KA-induced epileptic syndromes via suppression of NLRP3 inflammasome activation; therefore, offers a potential therapy for epilepsy.

Keywords:

Curcumin, recognition deficits, kainic acid induced epilepsy, NLRP3 inflammasomes, neuronal activity, inflammation.

Affiliation:

First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, First Cerebropathy Unit, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi



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