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Bradykinin Receptors in Ischemic Injury

[ Vol. 15 , Issue. 4 ]

Author(s):

Min Tang*, Fangping He, Li Ma, Ping Liu, Jianwen Wang and Xiongchao Zhu   Pages 359 - 366 ( 8 )

Abstract:


Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed.

Keywords:

Kallikrein-Kinin System (KKS), Bradykinin (BK), B1 Receptor (B1R), B2 Receptor (B2R), myocardial ischemia, ischemia/reperfusion, hypoxia/reperfusion, angiogenesis, apoptosis.

Affiliation:

Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003, Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003, Department of Neurology, Shaoxing Second Hospital, #123 Yan'an Road, Yuecheng District, Shaoxing, Zhejiang Province 312000, Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003, Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003, Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003



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