Antonio Siniscalchi*, Piergiorgio Lochner, Sabrina Anticoli, Domenico Chirchiglia, Giovambattista De Sarro and Luca Gallelli
Increasing evidence support the relationship between vitamin D and stroke. Vitamin D have now been proposed as a prognostic biomarker for also functional outcome in stroke patients. A revision of the data suggests that low vitamin D is associated more with ischemic than with haemorrhagic stroke, even if the role of optimal vitamin D levels for vascular wall is still unclear. Vitamin D deficiency induces with different mechanisms an alteration of vascular wall. However, to date, the research supporting the effectiveness of vitamin D supplementation in stroke and in post-stroke recovery is still inadequate and conclusive evidences have not been published. In this review, we provide a better understanding of the role of vitamin D in stroke.
stroke, Vitamin D, biomarker, supplementation Vitamin D
Department of Neurology and Stroke Unit, “Annunziata” Hospital, Cosenza, Department of Neurology, Saarland University Medical Center, Homburg, Stroke Unit, San Camillo-Forlanini Hospital , Rome , Department of Medical and Surgical Science, School of Medicine, University of Catanzaro, Catanzaro, Department of Medical and Surgical Science, School of Medicine, University of Catanzaro, Catanzaro, Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology Unit, Mater Domini University Hospital, Catanzaro