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Vascular Morphology has No Direct Relationship with Atherosclerotic Plaque Burden in Patients with Symptomatic Middle Cerebral Artery Stenosis

[ Vol. 16 , Issue. 3 ]

Author(s):

Lu Liu, Chengju Huo, Hao Sun, Hua Yang, Rui Zhang, Le-xin Wang* and Zhangyong Xia   Pages 224 - 231 ( 8 )

Abstract:


Background: The vascular morphology and the characteristics of atherosclerotic plaques in the middle cerebral artery (MCA) have not been fully studied with high-resolution magnetic resonance imaging (HR-MRI).

Objective: HR-MRI was applied to investigate vascular morphology and atherosclerotic plaque in patients with symptomatic MCA stenosis.

Materials and Methods: A total of 343 patients with symptomatic MCA stenosis were enrolled in this study. All the patients were examined by HR-MRI to analyze the morphology of MCA and the M1 segment (MCA-M1), the characteristics and the location of the plaques.

Results: The proportion of L-shaped MCA-M1 decreased, while the proportion of S-shaped MCAM1 increased with age. The anterior plaques were the most common in all the patients. The superior plaques were relatively common in patients with L-shaped and U-shaped MCA-M1, while the inferior plaques were relatively common in patients with inverted U-shaped and S-shaped MCAM1. Among all the plaques, the majority were isointense or heterogeneous. The MCA-M1 morphology had no direct relationship with the common risk factors of atherosclerosis and the clinical outcomes of the patients after 12 months of follow up.

Conclusion: The morphology of MCA-M1 is not directly related to the plaque burden or the degree of stenosis in patients with symptomatic MCA stenosis. The morphology of MCA-M1 is not associated with the risk factors of atherosclerosis, or the clinical outcomes of the patients.

Keywords:

High-resolution magnetic resonance imaging, middle cerebral artery, vascular morphology, atherosclerotic plaque, stroke, cerebral artery stenosis.

Affiliation:

Department of Neurology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, Department of Neurology, the Third People's Hospital of Liaocheng, Liaocheng, Shandong, 252000, Department of Neurology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, Department of Neurology, the Third People's Hospital of Liaocheng, Liaocheng, Shandong, 252000, Department of Neurology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, Department of Neurology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000



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