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Early Post-stroke Depressive Symptoms are Associated with Low Peripheral Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) and Glial Cell-derived Neurotrophic Factor (GDNF)

[ Vol. 17 , Issue. 4 ]

Author(s):

Vinicius S.P. Pedroso*, √Črica L.M. Vieira, Aline S. de Miranda, Venugopal R. Venna, Louise D. McCullough and Antonio L. Teixeira   Pages 495 - 501 ( 7 )

Abstract:


Background: Stroke is a major cause of death and disability worldwide. Among its complications, post-stroke depression (PSD) leads to a significant burden. The diagnosis of PSD is complex, and there are no biomarkers that can assist in its early identification and adequate management.

Objective: The aim of the present study is to investigate peripheral biomarkers in the acute phase of stroke and their potential association with depressive symptoms.

Methods: We evaluated 60 patients in the acute phase of stroke by using standardized instruments of psychiatric and neurological assessment (Mini International Neuropsychiatric Interview-Plus- MINI-Plus, Hospital Anxiety and Depression Scale-HADS, and National Institutes of Health Stroke Scale-NIHSS) and measured peripheral biomarkers.

Results: In multivariate analysis, low peripheral levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and higher NIHSS scores were associated with PSD. The severity of depressive symptoms was inversely correlated with sTREM-1 and glial cell-derived neurotrophic factor (GDNF) levels.

Conclusion: This is the first study indicating an association between sTREM-1 and PSD. Our results may point to the involvement of glial mechanisms in the manifestation of depressive symptoms after stroke.

Keywords:

Stroke, post-stroke depression, biomarkers, sTREM-1, GDNF, cognitive dysfunction.

Affiliation:

Stroke Branch, Neuroscience Division, Interdisciplinary Laboratory of Medicinal Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Stroke Branch, Neuroscience Division, Interdisciplinary Laboratory of Medicinal Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Stroke Branch, Neuroscience Division, Interdisciplinary Laboratory of Medicinal Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, BRAINS Lab, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, BRAINS Lab, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, Instituto de Ensino e Pesquisa, Santa Casa BH, Belo Horizonte



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