Submit Manuscript  

Article Details


Impact of Endothelial NOS VNTR Variant on Susceptibility to Diabetic Neuropathy and Type 2 Diabetes Mellitus

[ Vol. 17 , Issue. 5 ]

Author(s):

Serbulent Yigit*, Ayse Feyda Nursal, Suheyla Uzun, Husniye Rustemoglu, Payam Amiri Dashatan, Huseyin Soylu, Aysegul Atmaca, Aydin Rustemoglu, Nilufer Kuruca and Nevin Karakus   Pages 700 - 705 ( 6 )

Abstract:


Purpose: The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN.

Methods: A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was genotyped by polymerase chain reaction (PCR) method.

Results: eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively).

Conclusion: The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to the risk of these disorders.

Keywords:

Endothelial NOS VNTR variant, diabetes mellitus, hyperglycemia, diabetic peripheral neuropathy, genotype, peripheral nerve.

Affiliation:

Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Department of Medical Genetics, Faculty of Medicine, Hitit University, Corum, Department of Internal Medicine, Gaziosmanpasa University School of Medicine, Tokat, Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Department of Internal Medicine, Ondokuz Mayis University, Samsun, Department of Internal Medicine, Ondokuz Mayis University, Samsun, Department of Medical Biology, Faculty of Medicine, Aksaray University, Aksaray, Department of Veterinary Pathology, Faculty of Veterinary, Ondokuz Mayıs University, Samsun, Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat

Graphical Abstract:



Read Full-Text article