Simona Moretti, Antonio Procopio, Massimo Boemi and Alfonso Catalano Pages 295 - 305 ( 11 )
Semaphorins are involved in a wide range of biological processes, including axon guidance, neuronal migration, angiogenesis, cardio- and osteo-genesis. Recently they have also been found to be important for immune response. Sema3A reduces the activation of T cells through its cell-surface receptors, including members of the neuropilin and plexin families. By contrast, Sema4D (CD100), which is expressed on the surface of T, B and dendritic cells, increases B cell and dendritic cell function using either plexin B1 or CD72 as receptors. The transmembrane protein Sema4A is involved in the activation of immune cells through interactions with Tim-2. Emerging evidence also indicates that additional semaphorins and related molecules seem to function in the reciprocal stimulation of T cells and antigen-presenting cells (APCs). This paper discusses the functions of these semaphorins in the immune system, focusing on their roles in T cell- APC interactions.
Immune semaphorins, immune system, nervous system, semaphorin pathways, Sema-3A, Sema-4A, Sema-4D
Dipartimento di Patologia Molecolare e Terapie Innovative, Universita Politecnica delle Marche, Via Ranieri, 60131, Ancona, Italy.