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Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases

[ Vol. 18 , Issue. 1 ]

Author(s):

Flavio M. Ceci, Mauro Ceccanti, Carla Petrella, Mario Vitali, Marisa P. Messina, George N. Chaldakov, Antonio Greco, Massimo Ralli, Marco Lucarelli, Antonio Angeloni, Marco Fiore* and Giampiero Ferraguti   Pages 150 - 161 ( 12 )

Abstract:


Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers due to their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. According to an extensive literature body, ethanol intoxication modifies lipid serum profile and induces endothelial dysfunction. Single nucleotide polymorphisms may influence the relationship between alcohol drinking, HDL cholesterol level, and atherosclerotic risk. The risk of ACVD in heavy drinkers seems enhanced in patients with apolipoprotein E4 allele, interleukin- 6-174 polymorphism, and cholesteryl ester transfer protein TaqIB polymorphism. Apolipoprotein E4 is a known risk factor for ACVD, while apolipoprotein E2 has mixed effects. Therefore, even if a “protective role” may be attributed to moderate drinking, this effect cannot be extended to everyone.

Keywords:

Alcoholism, genetic polymorphism, atherosclerotic cardiovascular disease, apolipoprotein E, adiponectin.

Affiliation:

Department of Experimental Medicine, Sapienza University of Rome, Rome, Sitac, Societa’ Italiana per lo Studio delle Patologie Alcool Derivate. Rome, Section of Neurobiology, Institute of Biochemistry and Cell Biology (IBBC-CNR), Rome, ASUR Marche, AV4, Ancona, Department of Gynecology, Obstetric, and Urology, Sapienza University of Rome, Department of Anatomy and Cell Biology, Medical University, and Institute for Advanced Study, Varna, Department of Sense Organs, Medical faculty, Sapienza University of Rome, Rome, Department of Sense Organs, Medical faculty, Sapienza University of Rome, Rome, Department of Experimental Medicine, Sapienza University of Rome, Rome, Department of Experimental Medicine, Sapienza University of Rome, Rome, Section of Neurobiology, Institute of Biochemistry and Cell Biology (IBBC-CNR), Rome, Department of Experimental Medicine, Sapienza University of Rome, Rome



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